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Index > Protein center > Hjurp(Gene name) > Mouse
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  • Hjurp (Gene name),
  • Holliday junction recognition protein (Protein name ),  HJURP_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Hjurp(Fleg1);
    Protein name:
    Holliday junction recognition protein;
    Alternative:
    Fetal liver expressing gene 1 protein homolog(mFleg1);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with CENPA (via CATD domain); the interaction is direct and specific for CENPA since it does not interact with H3.1- or H3.3-containing nucleosomes. Heterotrimer composed of HJURP, CENPA and histone H4, where HJURP interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4. Interacts with 14-3-3 family members in a phosphorylation-dependent manner. Interacts with MSH5 and NBN.
    Function:
    Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.
    Subcellular Location:
    Nucleus nucleolus Chromosome centromere Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.
    Protein Attributes:
    Sequence length:
    667
    Sequence:
    50:
    MESMGRQDRR | LHQQLKESSS | RFQTLMKRLI | AKYNQPFEDD | PLVEMRTLTY | 
    100:
    ETPQGLRVWG | GKLMKKEDKE | YTQVIDRLNG | QAPEGDSESS | GADTSLEENW | 
    150:
    PSCSSAMREA | SGDPRQRQPA | VPGNTLETDL | RRKYLTQVDI | LPQDEEYFKN | 
    200:
    AEKRGGKDTV | MTWVPSVTSS | VTPASGCQDA | ISAKSSGGPE | VSALSSRGQG | 
    250:
    PSYPCPADMA | IVARSDGLSL | LGTSSNSVSS | QSFEVDDLCN | VTISDLYEGM | 
    300:
    MHSMSRLLRS | KPSCIISTKT | YINQSWKLRR | RPSRKQGLHK | NRTHCPRSKP | 
    350:
    SQRSARKGPA | SCSEPGKEAG | ILRDYGNLLH | VAPHKTGLEL | KSVSLEGSKR | 
    400:
    QVHKSSPAWK | ELQMMPQKDL | DLNRERENRV | MTLQWLISPV | KVVPRPRMLP | 
    450:
    SQVEKWYREI | KIKFDKLHQE | YCLSSGKQPR | LTDPTESWAV | DVYRSGSKSP | 
    500:
    GSRQDVETCR | PSSPFGREKT | ERPGEALEDL | RGNGKSVKTK | SCLLRSCPSP | 
    550:
    EGSPSRSPSH | SQLSSGLQEH | NSEPTGKAVW | PSTAISAPSI | GSPGCGKDNY | 
    600:
    YELKKEFNRL | YQKYCLSPQR | AKVTSCGRVS | PMKAAAALPC | QSEHLKRLNP | 
    650:
    DSPQQSSQKR | SISPGCHRRV | LQDSTAQTAS | TLVRDSWLPT | KRCKLSYPVA | 
    667:
    CAHQAKFHDT | SGASGWP
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Holliday junction recognition protein
    Cat.:
    E2156h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Holliday junction recognition protein
    Cat.:
    E2156m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Holliday junction recognition protein
    Cat.:
    U2156h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Holliday junction recognition protein
    Cat.:
    U2156m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Holliday junction recognition protein
    Cat.:
    P2156Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Holliday junction recognition protein
    Cat.:
    P2156Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Holliday junction recognition protein
    Monoclonal Antibody for Mouse Holliday junction recognition protein
    Protein for Mouse Holliday junction recognition protein
    Protein for Mouse Holliday junction recognition protein

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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Impaired cytoplasmic localization and nuclear accumulation of a novel gene product, hFLEG1, associated with hepatocellular carcinoma development."
      Koike N. , Sumii M. , Ikura T. , Masuda Y. , Wakida K. , Uchida T. , Asahara T. , Usui T. , Shimamoto F. , Chayama K. , Fukumoto M. , Kamiya K.
      Submitted (2004-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      strain: C57BL/6J.
      tissue: Cerebellum.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      strain: C57BL/6.
      tissue: Brain.
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